Exposure to per- and polyfluoroalkyl substances and premature skin aging

Per- and polyfluoroalkyl substances (PFASs) are a ubiquitous group of persistent chemicals distributed globally in the environment. Skin aging is notorious process that prematurely induced by interaction between endogenous exogenous factors, including exposure to environmental chemicals. The existing evidence suggests skin absorption PFASs through dermal contact may be an important route these humans. On other hand, intake routes lead bioaccumulation via tissue bio-distribution. Additionally, presence consumer cosmetic products combined with their daily close could render humans readily susceptible absorption. Therefore, chronic low-dose can occur human population, representing another Studies indicate threaten health contribute premature aging. Initiation inflammatory-oxidative cascades, induction DNA damage such as telomere shortening, dysregulation genes engaged barrier integrity its functions, signaling mitogen activated protein kinase (MAPK) pathway, last but not least down-regulation extracellular matrix (ECM) components among most likely mechanisms which